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KMID : 0614620090540060377
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Korean Journal of Gastroenterology
2009 Volume.54 No. 6 p.377 ~ p.383
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Association of Toll-Like Receptor Gene with Crohn’s Disease in Koreans
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Ye Byong-Duk
Byeon Jeong-Sik
Myung Seung-Jae
Yang Suk-Kyun
Kim Jin-Ho
Yang Dong-Hoon
Yoon Soon-Man
Kim Kyung-Jo
Song Kyu-Young
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Abstract
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Backgrounds/Aims: Toll-like receptors (TLRs) serve as pattern recognition receptors that recognize specific molecular patterns of pathogens and can mediate the production of proinflammatory cytokines. Recently, TLRs have been identified as susceptibility genes for Crohns disease (CD) in several studies from Western populations. We investigated the association of genetic variations in TLR4 and TLR9 with CD in Korean population.
Methods: In 380 CD cases and 380 healthy controls, we performed genotyping for TLR4 Asp299Gly (rs4986790) and Thr399Ile (rs4986791). The genetic variations in the TLR9 -1237T/C (rs5743836) were also examined.
Results: Among CD patients genotyped for TLR4 Asp299Gly and TLR9 -1237T/C, none had variant alleles. Similarly, none of the subjects genotyped for TLR4 Thr399Ile showed genetic variations.
Conslusions: Our results indicate that the major genetic variations in TLR4 and TLR9 are rare and may not be associated with susceptibility to CD in Koreans.
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KEYWORD
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Crohns disease, Toll-like receptor, Korea
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